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Article

Spry1 and Spry2 are necessary for eyelid closure.

Developmental biology - 15 Nov 2013

Kuracha Murali R, Siefker Ed, Licht Jonathan D, Govindarajan Venkatesh

Abstract excerpt

Sproutys (Sprys) are downstream targets and negative feedback regulators of the FGF-Ras-ERK signaling pathway. Our previous studies have shown that Spry1 and Spry2, through negative modulation of FGF-ERK signaling, allow lens vesicle separation from the overlying ectoderm and regulate corneal epithelial proliferation. Here we show that Spry1 and Spry2 are necessary for eyelid closure. Murine palpebral...

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Share to Bone Morphogenetic Protein 4
Share to Epidermal Cells
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eyelids

Share to Fibroblast Growth Factors

Share to Hedgehog Proteins

Share to Proto-Oncogene Proteins c-jun

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 24055172
DOI: 10.1016/j.ydbio.2013.09.014
PMCID: PMC3857020

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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