Article
Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis.
Cell death and differentiation - 1 Feb 2014
Macià A, Vaquero M, Gou-Fàbregas M, Castelblanco E, Valdivielso J M, Anerillas C, Mauricio D, Matias-Guiu X, Ribera J, Encinas M
Abstract excerpt
Genes of the Sprouty family (Spry1-4) are feedback inhibitors of receptor tyrosine kinase (RTK) signaling. As such, they restrain proliferation of many cell types and have been proposed as tumor-suppressor genes. Although their most widely accepted target is the Extracellular-regulated kinases (ERK) pathway, the mechanisms by which Spry proteins inhibit RTK signaling are poorly understood. In the present work, we...
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