Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development.

doi:10.1242/dev.01200

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Article

Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development.

Development (Cambridge, England) - 1 Jul 2004

Chi Lijun, Zhang Shaobing, Lin Yanfeng, Prunskaite-Hyyryläinen Renata, Vuolteenaho Reetta, Itäranta Petri, Vainio Seppo

Abstract excerpt

The kidney is a classic model for studying mechanisms of inductive tissue interactions associated with the epithelial branching common to many embryonic organs, but the molecular mechanisms are still poorly known. Sprouty proteins antagonize tyrosine kinases in the Egf and Fgf receptors and are candidate components of inductive signalling in the kidney as well. We have addressed the function of sprouty proteins...

Topics

Adaptor Proteins, Signal Transducing
Animals
Bromodeoxyuridine
Cell Division
Drosophila Proteins
Epithelium
Fibroblast Growth Factor 7
Fibroblast Growth Factors
Glial Cell Line-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycoproteins

Growth Substances

Humans

Image Processing, Computer-Assisted

Intracellular Signaling Peptides and Proteins

Kidney

Membrane Proteins

Mesoderm

Mice

Source

Open in PubMed

Identifiers

PMID: 15201220
DOI: 10.1242/dev.01200

Genes

SPRY2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development.PMID 15201220Read ↗

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