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Article

Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation.

The Journal of biological chemistry - 28 Sept 2001

Sasaki A, Taketomi T, Wakioka T, Kato R, Yoshimura A

Abstract excerpt

Various mitogenic stimuli such as epidermal growth factor (EGF), fibroblast growth factor (FGF), and phorbol 12,13-dibutyrate (PDBu) activate the Ras-Raf-MEK-ERK pathway, but the regulatory mechanism of this pathway remains to be investigated. Here we found that in 293 cells, mammalian Sprouty2 and Sprouty4 were rapidly induced by EGF, FGF, and PDBu in an ERK pathway-dependent manner. Forced expression of...

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Identifiers

PMID: 11495895
DOI: 10.1074/jbc.C100386200

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation.PMID 11495895Read ↗

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.Semantic proximity Read ↗

Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation.Semantic proximity Read ↗

Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.Semantic proximity Read ↗

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.Semantic proximity Read ↗

The Sprouty/Spred family as tumor suppressors: Coming of ageSemantic proximity Read ↗

Sprouty gain of function disrupts lens cellular processes and growth by restricting RTK signaling.Semantic proximity Read ↗

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.Semantic proximity Read ↗

Mutation of Spry2 induces proliferation and differentiation of osteoblasts but inhibits proliferation of gingival epithelial cells.Semantic proximity Read ↗

Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF.Semantic proximity Read ↗

Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.Semantic proximity Read ↗

Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction.Semantic proximity Read ↗

Down-regulation of Sprouty2 in non-small cell lung cancer contributes to tumor malignancy via extracellular signal-regulated kinase pathway-dependent and -independent mechanisms.Semantic proximity Read ↗

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