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Article

sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish.

Development (Cambridge, England) - 1 Jun 2001

Fürthauer M, Reifers F, Brand M, Thisse B, Thisse C

Abstract excerpt

In looking for novel factors involved in the regulation of the fibroblast growth factor (FGF) signaling pathway, we have isolated a zebrafish sprouty4 gene, based on its extensive similarities with the expression patterns of both fgf8 and fgf3. Through gain- and loss-of-function experiments, we demonstrate that Fgf8 and Fgf3 act in vivo to induce the expression of Spry4, which in turn can inhibit activity of...

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Source

Identifiers

PMID: 11493538
DOI: 10.1242/dev.128.12.2175

Genes

FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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