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Article

Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice.

PloS one - 1 Jan 2012

Capsoni Simona, Marinelli Sara, Ceci Marcello, Vignone Domenico, Amato Gianluca, Malerba Francesca, Paoletti Francesca, Meli Giovanni, Viegi Alessandro, Pavone Flaminia, Cattaneo Antonino

Abstract excerpt

Nerve Growth Factor (NGF) is being considered as a therapeutic candidate for Alzheimer's disease (AD) treatment but the clinical application is hindered by its potent pro-nociceptive activity. Thus, to reduce systemic exposure that would induce pain, in recent clinical studies NGF was administered through an invasive intracerebral gene-therapy approach. Our group demonstrated the feasibility of a non-invasive...

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Identifiers

PMID: 22666365
DOI: 10.1371/journal.pone.0037555
PMCID: PMC3364340

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice.PMID 22666365Read ↗

Development of a non invasive NGF-based therapy for Alzheimer's disease.Semantic proximity Read ↗

Functional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a "Painless" Lead Investigational Candidate for Therapeutic Applications.Semantic proximity Read ↗

Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity.Semantic proximity Read ↗

A Missense Point Mutation in Nerve Growth Factor (NGF <sup>R100W</sup> ) Results in Selective Peripheral Sensory NeuropathySemantic proximity Read ↗

The NGFR100W Mutation Specifically Impairs Nociception without Affecting Cognitive Performance in a Mouse Model of Hereditary Sensory and Autonomic Neuropathy Type V.Semantic proximity Read ↗

Swedish Nerve Growth Factor Mutation (NGF <sup>R100W</sup> ) Defines a Role for TrkA and p75NTR in NociceptionSemantic proximity Read ↗

In vitro receptor binding properties of a "painless" NGF mutein, linked to hereditary sensory autonomic neuropathy type V.Semantic proximity Read ↗

Swedish Nerve Growth Factor Mutation (NGF R100W ) Defines a Role for TrkA and p75 NTR in NociceptionSemantic proximity Read ↗

Understanding pain perception through genetic painlessness diseases: The role of NGF and proNGF.Semantic proximity Read ↗

Sex-dependent effects of the targeted nerve growth factor mutation (R100E) on pain behavior, joint inflammation, and bone erosion in mice.Semantic proximity Read ↗

A congenital pain insensitivity mutation in the nerve growth factor gene uncouples nociception from affective pain in heterozygous humans and miceSemantic proximity Read ↗

Single-Fiber Recordings of Nociceptive Fibers in Patients With HSAN Type V With Congenital Insensitivity to Pain.Semantic proximity Read ↗

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