Construction of a mutated pro-nerve growth factor resistant to degradation and suitable for biophysical and cellular utilization.

doi:10.1073/pnas.0604139103

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Article

Construction of a mutated pro-nerve growth factor resistant to degradation and suitable for biophysical and cellular utilization.

Proceedings of the National Academy of Sciences of the United States of America - 21 Nov 2006

Pagadala Promila C, Dvorak Laura A, Neet Kenneth E

Abstract excerpt

Precursor of nerve growth factor (proNGF) has been found to be proapoptotic in several cell types and mediates its effects by binding to p75 neurotrophin receptor (p75NTR) and sortilin. The proNGF molecule is processed by proteases at three dibasic sites found in the pro domain to form mature NGF (termed herein as sites 1, 2, and 3 from the proNGF N terminus). Of these processing sites, site 3, adjacent to the N...

Topics

Animals
Cell Line
Insecta
Mice
Mutation
Nerve Growth Factor
Proprotein Convertases
Protein Precursors
Protein Processing, Post-Translational
Rats

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PMID: 17093052
DOI: 10.1073/pnas.0604139103
PMCID: PMC1693851

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