Article
Construction and preliminary characterization of human recombinant proNGF-A variant.
Neurochemistry international - 1 Nov 2020
Soligo Marzia, Chiaretti Antonio, Leotta Eleonora, Lardone Elena, Boschelle Chiara, Mantuano Elide, Veneziano Liana, Manni Luigi
Abstract excerpt
The precursor of Nerve Growth Factor (proNGF) is the predominant form of NGF in the brain, where its tissue levels are increased in neurodegenerative diseases. proNGF exists in two main splicing variants, the long proNGF-A and the short proNGF-B. We demonstrated that proNGF-B is selectively increased in the hippocampus of rats affected by early diabetic encephalopathy and that native, purified proNGFs elicit...
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