Article
In vitro receptor binding properties of a "painless" NGF mutein, linked to hereditary sensory autonomic neuropathy type V.
Biochemical and biophysical research communications - 1 Jan 2010
Covaceuszach Sonia, Capsoni Simona, Marinelli Sara, Pavone Flaminia, Ceci Marcello, Ugolini Gabriele, Vignone Domenico, Amato Gianluca, Paoletti Francesca, Lamba Doriano, Cattaneo Antonino
Abstract excerpt
Nerve Growth Factor (NGF) signalling is mediated by the TrkA and p75NTR receptors. Besides its neurotrophic and survival activities, NGF displays a potent pro-nociceptive activity. Recently, a missense point mutation was found in the NGFB gene (C661T, leading to the aminoacid substitution R100W) of individuals affected by a form of hereditary loss of pain perception (hereditary sensory and autonomic neuropathy...
Topics
- Escherichia coli
- Hereditary Sensory and Autonomic Neuropathies
- Humans
- Mutation
- Nerve Growth Factor
- Nerve Tissue Proteins
- Pain Insensitivity, Congenital
- Protein Conformation
- Receptor, trkA