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Article

TPH2 gene polymorphisms and bipolar disorder: A meta-analysis.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2016

Gao Jin, Jia Mingrui, Qiao Dongdong, Qiu Huimin, Sokolove Jeremy, Zhang Jingxuan, Pan Zhenglun

Abstract excerpt

BACKGROUND: Disturbance of the serotonergic system contributes to the etiology of bipolar disorder (BD). Tryptophan hydroxylase-2 (TPH2) is an important rate-limiting enzyme in the synthetic pathway for brain serotonin and has been suggested to play a role in BD. MATERIALS AND METHODS: We performed a systematic review and meta-analysis of all studies to date investigating the association studies between TPH2 and...

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Source

Identifiers

PMID: 26365518
DOI: 10.1002/ajmg.b.32381

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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