Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ALDH2 and 5-HT2A genes interacted in bipolar-I but not bipolar-II disorder.

Progress in neuro-psychopharmacology & biological psychiatry - 7 Aug 2012

Lee Sheng-Yu, Chen Shiou-Lan, Chang Yun-Hsuan, Chu Chun-Hsieh, Huang San-Yuan, Tzeng Nian-Sheng, Wang Chen-Lin, Lin Shih-Hsien, Lee I Hui, Yeh Tzung Lieh, Yang Yen Kuang, Lu Ru-Band

Abstract excerpt

OBJECTIVE: Clarifying the similarities and differences between the two most common subtypes of bipolar disorder, bipolar-I and bipolar-II, is essential for improving our understanding of them. Because the serotonergic system has been implicated in the pathogenesis of bipolar disorder, it may be important to investigate genes such as the aldehyde dehydrogenase 2 (ALDH2) and serotonin 2A receptor genes, which are...

Topics

Adult
Aldehyde Dehydrogenase
Aldehyde Dehydrogenase, Mitochondrial
Bipolar Disorder
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Polymorphism, Restriction Fragment Length

Receptor, Serotonin, 5-HT2A

Source

Identifiers

PMID: 22564712
DOI: 10.1016/j.pnpbp.2012.04.005

Genes

ALDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ALDH2 and 5-HT2A genes interacted in bipolar-I but not bipolar-II disorder.PMID 22564712Read ↗

The ALDH2 and DRD2/ANKK1 genes interacted in bipolar II but not bipolar I disorder.Semantic proximity Read ↗

TPH2 gene polymorphisms and bipolar disorder: A meta-analysis.Semantic proximity Read ↗

Genetic variation of the 5-HT2A receptor gene and bipolar affective disorder.Semantic proximity Read ↗

Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population.Semantic proximity Read ↗

Association between the serotonin 2A receptor gene and bipolar affective disorder in an Australian cohort.Semantic proximity Read ↗

There is no association between the serotonin receptor gene and bipolar I disorder in the Korean population.Semantic proximity Read ↗

Role of DRD2 and ALDH2 genes in bipolar II disorder with and without comorbid anxiety disorder.Semantic proximity Read ↗

Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population.Semantic proximity Read ↗

The interaction between BDNF and DRD2 in bipolar II disorder but not in bipolar I disorder.Semantic proximity Read ↗

Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorderSemantic proximity Read ↗

Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.Semantic proximity Read ↗

Further evidence supporting the association between 5HTR2C gene and bipolar disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.