Article
Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population.
Progress in neuro-psychopharmacology & biological psychiatry - 2 Jan 2015
Chen Shiqing, Huang Xiaoye, Yu Tao, Li Xin, Cao Yanfei, Li Xingwang, Xu Fei, Yang Fengping, Jesse Forrest Fabian, Xu Mingqing, Li Weidong, He Lin, He Guang
Abstract excerpt
OBJECTIVE: Bipolar disorder (BPD) is a serious and common mental disorder with high heritability. The serotonergic system is known to be implicated in the etiology of the disorder. Tryptophan hydroxylase isoform-2 (TPH2), which controls the synthesis of serotonin in the brain, has been suggested as a candidate gene for BDP. The aim of this study was to examine the association between the polymorphisms in TPH2 and...
Topics
- Adult
- Asian People
- Bipolar Disorder
- Case-Control Studies
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Polymorphism, Single Nucleotide