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Article

Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population.

Neuroscience bulletin - 1 Feb 2014

Xiang Bo, Yang Zhenxing, Lin Yin, Guan Lijie, Li Xuan, Deng Wei, Jiang Zeyu, Lao Guohui, Wang Qiang, Hao Xiaoyu, Liu Xiang, Wang Yingcheng, Zhao Liansheng, Ma Xiaohong, Li Tao, Cao Liping, Hu Xun

Abstract excerpt

Serotonin plays an important role in mood regulation, but the involvement of serotonin pathway genes in the development of bipolar I disorder (BP-I), a mood disorder, is not clear. We selected 21 single-nucleotide polymorphisms (SNPs) within the HTR2A gene, 8 within the SLC6A4 gene and 23 within the TPH2 gene for genotyping using the GoldenGate genotyping assay. A total of 375 patients with BP-I and 475 normal...

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Identifiers

PMID: 24136241
DOI: 10.1007/s12264-013-1380-5
PMCID: PMC5562572

Genes

TPH2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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