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Article

Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior.

Journal of psychiatric research - 1 Apr 2010

Campos Simone Becho, Miranda Débora Marques, Souza Bruno Rezende, Pereira Patricia Araújo, Neves Fernando Silva, Bicalho Maria Aparecida Camargos, Melillo Paulo Henrique Casadei, Tramontina Juliana, Kapczinski Flávio, Romano-Silva Marco Aurélio, Correa Humberto

Abstract excerpt

Bipolar disorder (BD) is a severe psychiatric illness characterized by the occurrence of elevated mood alternating with depressive episodes, having a estimated lifetime prevalence of 0.4-1.6% using DSM-IV criteria. Disturbances of the central serotonergic system has been associated with the pathophysiology of affective disorders and suicidal behavior. Tryptophan hydroxylase 2 (TPH2) which is a rate limiting...

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Source

Identifiers

PMID: 19800079
DOI: 10.1016/j.jpsychires.2009.09.007

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior.PMID 19800079Read ↗

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Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.Semantic proximity Read ↗

No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover.Semantic proximity Read ↗

Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population.Semantic proximity Read ↗

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Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors.Semantic proximity Read ↗

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Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study.Semantic proximity Read ↗

Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder.Semantic proximity Read ↗

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