Article
Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.
Human molecular genetics - 1 Jan 2008
Cichon Sven, Winge Ingeborg, Mattheisen Manuel, Georgi Alexander, Karpushova Anna, Freudenberg Jan, Freudenberg-Hua Yun, Babadjanova Gulia, Van Den Bogaert Ann, Abramova Lilia I, Kapiletti Sofia, Knappskog Per M, McKinney Jeffrey, Maier Wolfgang, Jamra Rami Abou, Schulze Thomas G, Schumacher Johannes, Propping Peter, Rietschel Marcella, Haavik Jan, Nöthen Markus M
Abstract excerpt
The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] controls a broad range of biological functions that are disturbed in affective disorder. In the brain, 5-HT production is controlled by tryptophan hydroxylase 2 (TPH2). In order to assess the possible contribution of TPH2 genetic variability to the aetiology of bipolar affective disorder (BPAD), we systematically investigated common and rare genetic...
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