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Article

Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder.

Psychiatric genetics - 1 Jun 2009

Roche Siobhan, McKeon Patrick

Abstract excerpt

Bipolar affective disorder (BPAD) is a highly inherited genetic disorder and may be caused in part by deficits in serotonergic neurotransmission. We investigated whether variants within the tryptophan hydroxylase-2 (TPH2) gene, which is required for the synthesis of serotonin (5-HT), are associated with susceptibility to developing BPAD. Thirteen single nucleotide polymorphisms (SNPs) within TPH2 were genotyped...

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Source

Identifiers

PMID: 19352219
DOI: 10.1097/YPG.0b013e32832a4f95

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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