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Article

Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts.

Biological psychiatry - 15 Jan 2007

Lopez Victor A, Detera-Wadleigh Sevilla, Cardona Imer, Kassem Layla, McMahon Francis J

Abstract excerpt

BACKGROUND: Bipolar affective disorder (BPAD) is a common mental illness that is strongly associated with suicide. Suicidal behavior is thought to result from an interaction of genetic, neurobiological, and psychosocial factors and tends to cluster in families, suggesting specific familial factors distinct from those that underlie BPAD itself. Serotonin signaling has long been implicated in both BPAD and suicide,...

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Source

Identifiers

PMID: 16806105
DOI: 10.1016/j.biopsych.2006.03.028

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts.PMID 16806105Read ↗

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