Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia.

doi:10.1016/j.psychres.2011.02.001

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Article

Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia.

Psychiatry research - 30 Aug 2011

Serretti Alessandro, Chiesa Alberto, Porcelli Stefano, Han Changsu, Patkar Ashwin A, Lee Soo-Jung, Park Moon Ho, Pae Chi-Un

Abstract excerpt

The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within the tryptophan hydroxylase 2 gene (TPH2) could be associated with major depression (MD), bipolar disorder (BD) and schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antidepressants, mood stabilizers and antipsychotics, respectively. One hundred forty-five patients with...

Topics

Adult
Analysis of Variance
Antidepressive Agents
Bipolar Disorder
Chi-Square Distribution
Depressive Disorder, Major
Female
Gene Frequency
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Male

Middle Aged

Polymorphism, Single Nucleotide

Psychiatric Status Rating Scales

Schizophrenia

Tryptophan Hydroxylase

Source

Open in PubMed

Identifiers

PMID: 21396719
DOI: 10.1016/j.psychres.2011.02.001

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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