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Article

Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.

Journal of virology - 1 Oct 2010

Wright Jaclyn K, Brumme Zabrina L, Carlson Jonathan M, Heckerman David, Kadie Carl M, Brumme Chanson J, Wang Bingxia, Losina Elena, Miura Toshiyuki, Chonco Fundisiwe, van der Stok Mary, Mncube Zenele, Bishop Karen, Goulder Philip J R, Walker Bruce D, Brockman Mark A, Ndung'u Thumbi

Abstract excerpt

The mechanisms underlying HIV-1 control by protective HLA class I alleles are not fully understood and could involve selection of escape mutations in functionally important Gag epitopes resulting in fitness costs. This study was undertaken to investigate, at the population level, the impact of HLA-mediated immune pressure in Gag on viral fitness and its influence on HIV-1 pathogenesis. Replication capacities of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 20702636
DOI: 10.1128/JVI.01084-10
PMCID: PMC2950592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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