Article
Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection.
Journal of virology - 1 Sept 2008
Brumme Zabrina L, Brumme Chanson J, Carlson Jonathan, Streeck Hendrik, John Mina, Eichbaum Quentin, Block Brian L, Baker Brett, Kadie Carl, Markowitz Martin, Jessen Heiko, Kelleher Anthony D, Rosenberg Eric, Kaldor John, Yuki Yuko, Carrington Mary, Allen Todd M, Mallal Simon, Altfeld Marcus, Heckerman David, Walker Bruce D
Abstract excerpt
During acute human immunodeficiency virus type 1 (HIV-1) infection, early host cellular immune responses drive viral evolution. The rates and extent of these mutations, however, remain incompletely characterized. In a cohort of 98 individuals newly infected with HIV-1 subtype B, we longitudinally characterized the rates and extent of HLA-mediated escape and reversion in Gag, Pol, and Nef using a rational...
Topics
- Acute Disease
- Alleles
- Amino Acid Sequence
- Epitopes, T-Lymphocyte
- Evolution, Molecular
- Genes, gag
- Genes, nef
- Genes, pol
- HIV Infections