Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection.

doi:10.1128/JVI.01086-10

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Article

Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection.

Journal of virology - 1 Nov 2010

Brockman Mark A, Brumme Zabrina L, Brumme Chanson J, Miura Toshiyuki, Sela Jennifer, Rosato Pamela C, Kadie Carl M, Carlson Jonathan M, Markle Tristan J, Streeck Hendrik, Kelleher Anthony D, Markowitz Martin, Jessen Heiko, Rosenberg Eric, Altfeld Marcus, Harrigan P Richard, Heckerman David, Walker Bruce D, Allen Todd M

Abstract excerpt

Mutations that allow escape from CD8 T-cell responses are common in HIV-1 and may attenuate pathogenesis by reducing viral fitness. While this has been demonstrated for individual cases, a systematic investigation of the consequence of HLA class I-mediated selection on HIV-1 in vitro replication capacity (RC) has not been undertaken. We examined this question by generating recombinant viruses expressing plasma...

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Identifiers

PMID: 20810731
DOI: 10.1128/JVI.01086-10
PMCID: PMC2977869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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