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Article

Frequent and variable cytotoxic-T-lymphocyte escape-associated fitness costs in the human immunodeficiency virus type 1 subtype B Gag proteins.

Journal of virology - 1 Apr 2013

Boutwell Christian L, Carlson Jonathan M, Lin Tien-Ho, Seese Aaron, Power Karen A, Peng Jian, Tang Yanhua, Brumme Zabrina L, Heckerman David, Schneidewind Arne, Allen Todd M

Abstract excerpt

Cytotoxic-T-lymphocyte (CTL) escape mutations undermine the durability of effective human immunodeficiency virus type 1 (HIV-1)-specific CD8(+) T cell responses. The rate of CTL escape from a given response is largely governed by the net of all escape-associated viral fitness costs and benefits. The observation that CTL escape mutations can carry an associated fitness cost in terms of reduced virus replication...

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Topics

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Share to gag Gene Products, Human Immunodeficiency Virus
Share to Genetic Fitness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Real-Time Polymerase Chain Reaction

Share to T-Lymphocytes, Cytotoxic

Share to Thermodynamics

Share to Virus Replication

Source

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Identifiers

PMID: 23365420
DOI: 10.1128/JVI.03233-12
PMCID: PMC3624202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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