Article
Differential escape patterns within the dominant HLA-B*57:03-restricted HIV Gag epitope reflect distinct clade-specific functional constraints.
Journal of virology - 1 May 2014
Payne R P, Branch S, Kløverpris H, Matthews P C, Koofhethile C K, Strong T, Adland E, Leitman E, Frater J, Ndung'u T, Hunter E, Haubrich R, Mothe B, Edwards A, Riddell L, Chen F, Harrigan P R, Brumme Z L, Mallal S, John M, Jooste J P, Shapiro R, Deeks S G, Walker B D, Brander C, Landis C, Carlson J M, Prado J G, Goulder P J R
Abstract excerpt
UNLABELLED: HLA-B*57:01 and HLA-B*57:03, the most prevalent HLA-B*57 subtypes in Caucasian and African populations, respectively, are the HLA alleles most protective against HIV disease progression. Understanding the mechanisms underlying this immune control is of critical importance, yet they remain unclear. Unexplained differences are observed in the impact of the dominant cytotoxic T lymphocyte (CTL) response...
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