Article
Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.
Genetics - 1 Nov 2015
Bailey Melanie L, Singh Tejomayee, Mero Patricia, Moffat Jason, Hieter Philip
Abstract excerpt
FBW7 (F-box and WD repeat domain containing 7), also known as FBXW7 or hCDC4, is a tumor suppressor gene mutated in a broad spectrum of cancer cell types. As a component of the SCF E3 ubiquitin ligase, FBW7 is responsible for specifically recognizing phosphorylated substrates, many important for...
Topics
- Aneuploidy
- Cell Cycle Proteins
- Cell Line, Tumor
- Cyclin E
- F-Box Proteins
- F-Box-WD Repeat-Containing Protein 7
- Gene Knockout Techniques
- Genes, Tumor Suppressor
- Humans
- M Phase Cell Cycle Checkpoints
- Mutation
- Protein Serine-Threonine Kinases