Article
MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression.
Cell cycle (Georgetown, Tex.) - 1 Jul 2011
Lerner Mikael, Lundgren Josefin, Akhoondi Shahab, Jahn Angelina, Ng Hwee-Fang, Akbari Moqadam Farhad, Oude Vrielink Joachim A F, Agami Reuven, Den Boer Monique L, Grandér Dan, Sangfelt Olle
Abstract excerpt
The F-box protein FBW7/hCDC4 is a tumor suppressor that acts as the substrate recognition component of an SCF ubiquitin ligase that targets numerous oncoproteins for proteasomal degradation. In this study, we investigated whether FBW7 is regulated by microRNAs, using a screen combining bioinformatic analysis, luciferase reporters and microRNA libraries. The ubiquitous miR-27a was identified as a major suppressor...
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