FBXW7/hCDC4 is a general tumor suppressor in human cancer.

doi:10.1158/0008-5472.CAN-07-1320

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Article

FBXW7/hCDC4 is a general tumor suppressor in human cancer.

Cancer research - 1 Oct 2007

Akhoondi Shahab, Sun Dahui, von der Lehr Natalie, Apostolidou Sophia, Klotz Kathleen, Maljukova Alena, Cepeda Diana, Fiegl Heidi, Dafou Dimitra, Dofou Dimitra, Marth Christian, Mueller-Holzner Elisabeth, Corcoran Martin, Dagnell Markus, Nejad Sepideh Zabihi, Nayer Babak Noori, Zali Mohammad Reza, Hansson Johan, Egyhazi Susanne, Petersson Fredrik, Sangfelt Per, Nordgren Hans, Grander Dan, Reed Steven I, Widschwendter Martin, Sangfelt Olle, Spruck Charles

Abstract excerpt

The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family of proteins, which are substrate recognition components of the multisubunit ubiquitin ligase SCF (Skp1-Cdc53/Cullin-F-box-protein), has been shown to mediate the ubiquitin-dependent proteolysis of several oncoproteins including cyclin...

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PMID: 17909001
DOI: 10.1158/0008-5472.CAN-07-1320

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