Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer

3 Apr 2012

Abstract excerpt

Colorectal cancer (CRC) remains a major cause of cancer mortality worldwide. Murine models have yielded critical insights into CRC pathogenesis, but they often fail to recapitulate advanced-disease phenotypes, notably metastasis and chromosomal instability (CIN). New models are thus needed to understand disease progression and to develop therapies. We sought to model advanced CRC by inactivating two tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22473991
DOI: 10.1128/mcb.00305-12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal CancerPMID 22473991Read ↗

F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor.Semantic proximity Read ↗

Clinical significance of FBXW7 loss of function in human cancersSemantic proximity Read ↗

Comprehensive characterization of FBXW7 mutational and clinicopathological profiles in human colorectal cancersSemantic proximity Read ↗

Tumor suppressor functions of FBW7 in cancer development and progressionSemantic proximity Read ↗

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradationSemantic proximity Read ↗

Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.Semantic proximity Read ↗

Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestinesSemantic proximity Read ↗

Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition.Semantic proximity Read ↗

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.Semantic proximity Read ↗

Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: Clinical significanceSemantic proximity Read ↗

Clinicopathologic characteristics of FBXW7-mutated colorectal adenocarcinoma and association with aberrant beta-catenin localization.Semantic proximity Read ↗

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.