Article

SCF <sup>FBXW7</sup> regulates G2-M progression through control of CCNL1 ubiquitination

2022-09-26

Abstract excerpt

FBXW7 , which encodes a substrate specific receptor of an SCF E3 ligase complex, is a frequently mutated human tumor suppressor gene known to regulate the post-translational stability of various proteins involved in cellular proliferation. Here, using genome-wide CRISPR screens we report a novel synthetic lethal genetic interaction between FBXW7 and CCNL1 and describe CCNL1 as a new substrate of the SCF-FBXW7 E3...

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Literature Corpus work: 78dd99bd-f116-50eb-b201-8bf4720fe849
DOI: 10.1101/2022.09.26.509608

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