Article
Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.
Cancer science - 1 Aug 2006
Fujii Yo, Yada Masayoshi, Nishiyama Masaaki, Kamura Takumi, Takahashi Hidehisa, Tsunematsu Ryosuke, Susaki Etsuo, Nakagawa Tadashi, Matsumoto Akinobu, Nakayama Keiichi I
Abstract excerpt
Fbxw7 (also known as Sel-10, hCdc4 or hAgo) is the F-box protein component of a Skp1-Cul1-F-box protein (SCF) ubiquitin ligase. Fbxw7 contributes to the ubiquitin-mediated degradation of cyclin E, c-Myc, Aurora-A, Notch and c-Jun, all of which appear to function as cell-cycle promoters and oncogenic proteins. Loss of Fbxw7 results in elevated expression of its substrates, which may lead to oncogenesis. However,...
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