Article
FBXW7-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe.
Cancer research communications - 21 Dec 2023
O'Brien Siobhan, Ubhi Tajinder, Wolf Lucie, Gandhi Krishna, Lin Sichun, Chaudary Naz, Dhani Neesha C, Milosevic Michael, Brown Grant W, Angers Stephane
Abstract excerpt
FBXW7 is a commonly mutated tumor suppressor gene that functions to regulate numerous oncogenes involved in cell-cycle regulation. Genome-wide CRISPR fitness screens identified a signature of DNA repair and DNA damage response genes as required for the growth of FBXW7-knockout cells. Guided by these findings, we show that FBXW7-mutant cells have high levels of replication stress, which results in a...
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