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Article

Recent insight into the role of FBXW7 as a tumor suppressor.

Seminars in cancer biology - 1 Dec 2020

Yumimoto Kanae, Nakayama Keiichi I

Abstract excerpt

FBXW7 (also known as Fbw7, Sel10, hCDC4, or hAgo) is a tumor suppressor and the most frequently mutated member of the F-box protein family in human cancers. FBXW7 functions as the substrate recognition component of an SCF-type E3 ubiquitin ligase. It specifically controls the proteasome-mediated degradation of many oncoproteins such as c-MYC, NOTCH, KLF5, cyclin E, c-JUN, and MCL1. In this review, we summarize...

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Identifiers

PMID: 32113998
DOI: 10.1016/j.semcancer.2020.02.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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