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Article

SCFFBXW7 regulates G2-M progression through control of CCNL1 ubiquitination.

EMBO reports - 6 Dec 2022

O'Brien Siobhan, Kelso Susan, Steinhart Zachary, Orlicky Stephen, Mis Monika, Kim Yunhye, Lin Sichun, Sicheri Frank, Angers Stephane

Abstract excerpt

FBXW7, which encodes a substrate-specific receptor of an SCF E3 ligase complex, is a frequently mutated human tumor suppressor gene known to regulate the post-translational stability of various proteins involved in cellular proliferation. Here, using genome-wide CRISPR screens, we report a novel synthetic lethal genetic interaction between FBXW7 and CCNL1 and describe CCNL1 as a new substrate of the SCF-FBXW7 E3...

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Identifiers

PMID: 36278408
DOI: 10.15252/embr.202255044
PMCID: PMC9724663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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