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Article

Tumor suppressor functions of FBW7 in cancer development and progression

21 Mar 2012

Abstract excerpt

FBW7 (F-box and WD repeat domain-containing 7) has been characterized as an onco-suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its anti-tumor function primarily by promoting the degradation of various oncoproteins, through which FBW7 regulates cellular proliferation, differentiation and causes genetic instability. In this review, we will discuss the role of FBW7 downstream...

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PMID: 22673505
DOI: 10.1016/j.febslet.2012.03.017

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