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Article

Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2014

Scott Glynis A, Laughlin Todd S, Rothberg Paul G

Abstract excerpt

Telomerase is frequently expressed in cancer and contributes to carcinogenesis. Two recent publications report the identification of a set of recurrent mutations in melanoma in the promoter of the telomerase reverse transcriptase gene (TERT) that appears to be the result of mutagenesis from ultraviolet (UV) radiation. Both groups reported that the mutations increase the transcription of TERT. This prompted our...

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Share to Aged, 80 and over
Share to Carcinoma, Basal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

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Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 24030752
DOI: 10.1038/modpathol.2013.167

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma.PMID 24030752Read ↗

TERT promoter mutations are frequent in cutaneous basal cell carcinoma and squamous cell carcinoma.Semantic proximity Read ↗

TERT promoter mutations in familial and sporadic melanoma.Semantic proximity Read ↗

TERT promoter mutations in skin cancer: the effects of sun exposure and X-irradiation.Semantic proximity Read ↗

TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma.Semantic proximity Read ↗

Highly recurrent TERT promoter mutations in human melanoma.Semantic proximity Read ↗

TERT Promoter Mutations and Telomerase in MelanomaSemantic proximity Read ↗

TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas.Semantic proximity Read ↗

Clinical and pathological characteristics of familial melanoma with germline TERT promoter variants.Semantic proximity Read ↗

TERT promoter mutations in cancer development.Semantic proximity Read ↗

Recurrent promoter mutations in melanoma are defined by an extended context-specific mutational signatureSemantic proximity Read ↗

Heterogeneity of TERT promoter mutations status in squamous cell carcinomas of different anatomical sites.Semantic proximity Read ↗

Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma.Semantic proximity Read ↗

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