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TERT promoter mutation positive oral cavity carcinomas, a clinically and genetically distinct subgroup of head and neck squamous cell carcinomas.

Head & neck - 1 Dec 2023

Saito Yuki, Kage Hidenori, Kobayashi Kenya, Yoshida Masafumi, Fukuoka Osamu, Yamamura Koji, Mukai Toshiyuki, Oda Katsutoshi, Yamasoba Tatsuya

Abstract excerpt

BACKGROUNDS: The importance of TERT promoter (pTERT) mutation of oral cavity squamous cell carcinoma (OCSCC) with clinical features and genetic alterations are not well recognized. METHODS: We retrospectively analyzed genetic data from multiple databases, including 260 cases from the C-CAT database, 407 cases from the MSK-MetTropism database, and 40 OCSCC datasets from in-house clinical samples. RESULTS: From...

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PMID: 37815002
DOI: 10.1002/hed.27540

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