TERT promoter hotspot mutations and their relationship with TERT levels and telomere erosion in patients with head and neck squamous cell carcinoma.

doi:10.1007/s00432-020-03130-z

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TERT promoter hotspot mutations and their relationship with TERT levels and telomere erosion in patients with head and neck squamous cell carcinoma.

Journal of cancer research and clinical oncology - 1 Feb 2020

Boscolo-Rizzo Paolo, Giunco Silvia, Rampazzo Enrica, Brutti Martina, Spinato Giacomo, Menegaldo Anna, Stellin Marco, Mantovani Monica, Bandolin Luigia, Rossi Marco, Del Mistro Annarosa, Tirelli Giancarlo, Dei Tos Angelo Paolo, Guerriero Angela, Niero Monia, Da Mosto Maria Cristina, Polesel Jerry, De Rossi Anita

Abstract excerpt

PURPOSE: To evaluate the prevalence of two recurrent somatic mutations (-124 C>T and -146 C>T) within the promoter of the gene encoding telomerase reverse transcriptase (TERT) as well as their relationship with TERT level, telomeres length, and outcome in patients with head and neck squamous cell carcinomas (HNSCCs). METHODS: We evaluate the prevalence of TERT promoter mutations, TERT levels, and telomere length...

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PMID: 31960186
DOI: 10.1007/s00432-020-03130-z

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