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Article

Studies of the TLR4-associated protein MD-2 using yeast-display and mutational analyses.

Molecular immunology - 1 Dec 2015

Mattis Daiva M, Chervin Adam S, Ranoa Diana R, Kelley Stacy L, Tapping Richard I, Kranz David M

Abstract excerpt

Bacterial lipopolysaccharide (LPS) activates the innate immune system by forming a complex with myeloid differentiation factor 2 (MD-2) and Toll-like receptor 4 (TLR4), which is present on antigen presenting cells. MD-2 plays an essential role in this activation of the innate immune system as a member of the ternary complex, TLR4:MD-2:LPS. With the goal of further understanding the molecular details of the...

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Source

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Identifiers

PMID: 26320630
DOI: 10.1016/j.molimm.2015.08.008
PMCID: PMC4623992

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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