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Article

Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin.

The Journal of biological chemistry - 29 May 2009

Resman Nusa, Vasl Jozica, Oblak Alja, Pristovsek Primoz, Gioannini Theresa L, Weiss Jerrold P, Jerala Roman

Abstract excerpt

Gram-negative bacterial endotoxin (i.e. lipopolysaccharide (LPS)) is one of the most potent stimulants of the innate immune system, recognized by the TLR4.MD-2 complex. Direct binding to MD-2 of LPS and LPS analogues that act as TLR4 agonists or antagonists is well established, but the role of MD-2 and TLR4 in receptor activation is much less clear. We have identified residues within the hairpin of MD-2 between...

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Identifiers

PMID: 19321453
DOI: 10.1074/jbc.M901429200
PMCID: PMC2685687

Genes

TLR4

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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