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Article

Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition.

The Journal of biological chemistry - 2 Jul 2004

Gruber Anton, Mancek Mateja, Wagner Hermann, Kirschning Carsten J, Jerala Roman

Abstract excerpt

The receptor complex resulting from association of MD-2 and the ectodomain of Toll-like receptor 4 (TLR4) mediates lipopolysaccharide (LPS) signal transduction across the cell membrane. We prepared a tertiary structure model of MD-2, based on the known structures of homologous lipid-binding proteins. Analysis of circular dichroic spectra of purified bacterially expressed MD-2 indicates high content of beta-type...

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Source

Identifiers

PMID: 15111623
DOI: 10.1074/jbc.M400993200

Genes

TLR4
NPC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition.PMID 15111623Read ↗

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