Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2006

Rallabhandi Prasad, Bell Jessica, Boukhvalova Marina S, Medvedev Andrei, Lorenz Eva, Arditi Moshe, Hemming Val G, Blanco Jorge C G, Segal David M, Vogel Stefanie N

Abstract excerpt

TLR4 is the signal-transducing receptor for structurally diverse microbial molecules such as bacterial LPS, respiratory syncytial virus fusion (F) protein, and chlamydial heat shock protein 60. Previous studies associated two polymorphic mutations in the extracellular domain of TLR4 (Asp(299)Gly and Thr(399)Ile) with decreased LPS responsiveness. To analyze the molecular basis for diminished responsiveness,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid
Share to Extracellular Space

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glycine

Share to Isoleucine

Share to Lipopolysaccharide Receptors

Share to Oligopeptides

Share to Threonine

Share to Toll-Like Receptor 4

Source

Identifiers

PMID: 16785528
DOI: 10.4049/jimmunol.177.1.322

Genes

TLR4
CD14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling.PMID 16785528Read ↗

Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I.Semantic proximity Read ↗

The TLR4 D299G and T399I SNPs are constitutively active to up-regulate expression of Trif-dependent genes.Semantic proximity Read ↗

Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets.Semantic proximity Read ↗

A mouse model of human TLR4 D299G/T399I SNPs reveals mechanisms of altered LPS and pathogen responses.Semantic proximity Read ↗

Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling.Semantic proximity Read ↗

TLR2 and TLR4 Expression During Bacterial InfectionsSemantic proximity Read ↗

Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor.Semantic proximity Read ↗

Structural Diversity and Mutational Challenges of Toll-Like Receptor 4 Antagonists as Inflammatory Pathway Blocker.Semantic proximity Read ↗

Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharide of TLR4 mutant alleles.Semantic proximity Read ↗

TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors.Semantic proximity Read ↗

Tlr4: central component of the sole mammalian LPS sensor.Semantic proximity Read ↗

Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.