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Article

Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I.

The Journal of biological chemistry - 23 Nov 2012

Ohto Umeharu, Yamakawa Natsuko, Akashi-Takamura Sachiko, Miyake Kensuke, Shimizu Toshiyuki

Abstract excerpt

BACKGROUND: TLR4 polymorphism replacing Asp-299 with Gly and Thr-399 with Ile (D299G/T399I) causes LPS hyporesponsiveness. RESULTS: TLR4(SNPs)·MD-2·LPS exhibits an agonistic 2:2:2 architecture. Local structural differences were observed around D299G, but not around T399I, SNP site. CONCLUSION: These local differences cause the modulation of surface properties of TLR4, which may affect ligand binding....

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Share to Amino Acid Sequence
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Share to Toll-Like Receptor 4

Source

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Identifiers

PMID: 23055527
DOI: 10.1074/jbc.M112.404608
PMCID: PMC3504774

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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