The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.

doi:10.4049/jimmunol.174.1.340

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Article

The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2005

Tsuneyoshi Naoko, Fukudome Kenji, Kohara Jun, Tomimasu Rika, Gauchat Jean-Francois, Nakatake Hiroshi, Kimoto Masao

Abstract excerpt

MD-1 and MD-2 are secretory glycoproteins that exist on the cell surface in complexes with transmembrane proteins. MD-1 is anchored by radioprotective 105 (RP105), and MD-2 is associated with TLR4. In vivo studies revealed that MD-1 and MD-2 have roles in responses to LPS. Although the direct binding function of MD-2 to LPS has been observed, the physiological function of MD-1 remains unknown. In this study, we...

Topics

Amino Acid Sequence
Animals
Antigens, CD
Antigens, Surface
Binding Sites
Carrier Proteins
Electrophoresis, Polyacrylamide Gel
Humans
Immunoblotting
Lipopolysaccharides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Antigen 96

Membrane Glycoproteins

Molecular Sequence Data

Mutagenesis, Site-Directed

Mutation

Phenylalanine

Receptors, Cell Surface

Toll-Like Receptor 4

Source

Open in PubMed

Identifiers

PMID: 15611257
DOI: 10.4049/jimmunol.174.1.340

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15611257-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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