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Article

The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2005

Tsuneyoshi Naoko, Fukudome Kenji, Kohara Jun, Tomimasu Rika, Gauchat Jean-Francois, Nakatake Hiroshi, Kimoto Masao

Abstract excerpt

MD-1 and MD-2 are secretory glycoproteins that exist on the cell surface in complexes with transmembrane proteins. MD-1 is anchored by radioprotective 105 (RP105), and MD-2 is associated with TLR4. In vivo studies revealed that MD-1 and MD-2 have roles in responses to LPS. Although the direct binding function of MD-2 to LPS has been observed, the physiological function of MD-1 remains unknown. In this study, we...

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Source

Identifiers

PMID: 15611257
DOI: 10.4049/jimmunol.174.1.340

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.PMID 15611257Read ↗

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