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Article

Mutational analysis of membrane and soluble forms of human MD-2.

The Journal of biological chemistry - 28 Apr 2006

Viriyakosol Suganya, Tobias Peter S, Kirkland Theo N

Abstract excerpt

Toll-like receptor 4 and MD-2 form a receptor for lipopolysaccharide (LPS), a major constituent of Gram-negative bacteria. MD-2 is a 20-25-kDa extracellular glycoprotein that binds to Tolllike receptor 4 (TLR4) and LPS and is a critical part of the LPS receptor. Here we have shown that the level of MD-2 expression regulates TLR4 activation by LPS. Using site-directed mutagenesis, we have found that glycosylation...

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Source

Identifiers

PMID: 16467306
DOI: 10.1074/jbc.M511627200

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutational analysis of membrane and soluble forms of human MD-2.PMID 16467306Read ↗

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A coding mutation within the first exon of the human MD-2 gene results in decreased lipopolysaccharide-induced signaling.Semantic proximity Read ↗

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