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Article

Structural Diversity and Mutational Challenges of Toll-Like Receptor 4 Antagonists as Inflammatory Pathway Blocker.

Drug development research - 1 Feb 2025

Batin Rahaman S K, Nandi Sandip K, Mandal Sudip Kumar, Debnath Utsab

Abstract excerpt

Toll-like receptor 4 (TLR4) is an important mediator that activates bacterial inflammation through its signaling pathway. It binds lipopolysaccharide (LPS) in the presence of myeloid differentiation protein 2 (MD2) to dimerise the TLR4-MD2-LPS complex. The TLR4 mediated signaling pathway stimulates cytokine production in humans, initiating inflammatory responses. Overactivation of the TLR4 pathway can trigger...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39690962
DOI: 10.1002/ddr.70031

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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