APC mutation correlated with poor response of immunotherapy in colon cancer.

doi:10.1186/s12876-023-02725-3

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Article

APC mutation correlated with poor response of immunotherapy in colon cancer.

BMC gastroenterology - 28 Mar 2023

Li Bing, Zhang Guoliang, Xu Xuejie

Abstract excerpt

OBJECTIVE: APC (adenomatous polyposis coli) gene mutation is a central initialization in colon cancer tumorigenesis. However, the connection between APC gene mutation and immunotherapy efficacy for colon cancer remains unknown. This study aimed to explore the impact of APC mutation on immunotherapy efficacy for colon cancer. METHODS: Colon cancer data from The Cancer Genome Atlas (TCGA) and Memorial Sloan...

Topics

Humans
Adenomatous Polyposis Coli
Biomarkers, Tumor
Colonic Neoplasms
Immunotherapy
Microsatellite Instability
Mutation

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Open in PubMed Open full text

Identifiers

PMID: 36977982
DOI: 10.1186/s12876-023-02725-3
PMCID: PMC10053134

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