Article
Specific Mutations in APC, with Prognostic Implications in Metastatic Colorectal Cancer.
Cancer research and treatment - 1 Oct 2023
Peng Huan, Ying Jun, Zang Jia, Lu Hao, Zhao Xiaokai, Yang Pengmin, Wang Xintao, Li Jieyi, Gong Ziying, Zhang Daoyun, Wang Zhiguo
Abstract excerpt
PURPOSE: Loss-of-function mutations in the adenomatous polyposis coli (APC) gene are common in metastatic colorectal cancer (mCRC). However, the characteristic of APC specific mutations in mCRC is poorly understood. Here, we explored the clinical and molecular characteristics of N-terminal and C-terminal side APC mutations in Chinese patients with mCRC. MATERIALS AND METHODS: Hybrid capture-based next-generation...
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