Article
p53 mutation is common in microsatellite stable, BRAF mutant colorectal cancers.
International journal of cancer - 1 Apr 2012
Bond Catherine E, Umapathy Aarti, Ramsnes Ingunn, Greco Sonia A, Zhen Zhao Zhen, Mallitt Kylie-Ann, Buttenshaw Ron L, Montgomery Grant W, Leggett Barbara A, Whitehall Vicki L J
Abstract excerpt
The majority of "serrated pathway" colorectal cancers have mutation of the BRAF oncogene and display the CpG island methylator phenotype (CIMP). Half these cancers have microsatellite instability (MSI) and an excellent prognosis. In the absence of MSI (microsatellite stable, MSS), BRAF mutation has been associated with a particularly poor prognosis. "Traditional pathway" cancers are BRAF wild type. Mutation of...
Topics
- Aged
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- DNA Modification Methylases
- DNA Repair Enzymes
- Female
- Genes, p53
- Humans
- Male
- Microsatellite Instability