Article
A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC.
Nature communications - 15 Jun 2016
Schell Michael J, Yang Mingli, Teer Jamie K, Lo Fang Yin, Madan Anup, Coppola Domenico, Monteiro Alvaro N A, Nebozhyn Michael V, Yue Binglin, Loboda Andrey, Bien-Willner Gabriel A, Greenawalt Danielle M, Yeatman Timothy J
Abstract excerpt
Colorectal cancer (CRC) is a highly heterogeneous disease, for which prognosis has been relegated to clinicopathologic staging for decades. There is a need to stratify subpopulations of CRC on a molecular basis to better predict outcome and assign therapies. Here we report targeted exome-sequencing of 1,321 cancer-related genes on 468 tumour specimens, which identified a subset of 17 genes that best classify CRC,...
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