Article
BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features.
The American journal of surgical pathology - 1 May 2012
Pai Reetesh K, Jayachandran Priya, Koong Albert C, Chang Daniel T, Kwok Shirley, Ma Lisa, Arber Daniel A, Balise Raymond R, Tubbs Raymond R, Shadrach Bonnie, Pai Rish K
Abstract excerpt
The association of BRAF V600E mutation and the presence of the CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) often confound analysis of BRAF mutation status and survival in colorectal carcinoma. We evaluated a consecutive series of proximal colonic adenocarcinomas for mismatch repair protein abnormalities/MSI, BRAF V600E mutation, and KRAS mutations in an attempt to determine the...
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