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Article

APC mutations and other genetic and epigenetic changes in colon cancer.

Molecular cancer research : MCR - 1 Feb 2007

Samowitz Wade S, Slattery Martha L, Sweeney Carol, Herrick Jennifer, Wolff Roger K, Albertsen Hans

Abstract excerpt

Relationships between adenomatous polyposis coli (APC) mutations, BRAF V600E mutations, and the CpG island methylator phenotype (CIMP) in colon cancer have not been explored. In addition, controversies exist about the proportion of tumors with APC mutations in the mutation cluster region (MCR); how commonly APC, Ki-ras, and p53 mutations occur in the same tumor; and whether APC mutations occur in sporadic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17293392
DOI: 10.1158/1541-7786.MCR-06-0398

Genes

APC
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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